Is it safe to delete Mail attachment copies?
Re-downloads when needed Yes, but it has to be fetched again.
Copies of attachments you opened from Mail. The originals stay in your mailbox, but an attachment you opened, edited and saved exists only here.
Mail uses it while open, so ClearMac skips it until you quit Mail.
Where it is
~/Library/Containers/com.apple.mail/Data/Library/Mail Downloads
What “Re-downloads when needed” means
It can be downloaded or reinstalled again, but that takes time and data, and sometimes you have to do it yourself. ClearMac lists these items but never pre-selects them.
How ClearMac handles it
ClearMac lists it with this label but never pre-selects it. If you choose it, it goes to the Trash, so you can put it back until you empty the Trash.
This page is generated from the same rule ClearMac uses on your Mac (mail.downloads), so the app and this page always say the same thing.